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KMID : 0378019740170030331
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New Medical Journal
1974 Volume.17 No. 3 p.331 ~ p.344
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A Study on Development and Cytoarchitectonics of Cerebral Cortex in Opercular Part of Inferior Frontal Cyrus (Brodmann´s Area 44) in Normal Korean Fetus
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Abstract
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The authors have made a study of the quantitative changes in the early development of ´human brain with special reference to the growth and the cytoarchitectonics of cerebral cortex in the opercular part of the inferior frontal gyrus(Brodmann´s Area 44 & Broca´s center of speech) in a sample of 121 Korean fetal brains (65 of male & 56 of female) of which the age ranged from 5th month to completion of fetal life. The summary of the findings is as follows:
1. The average thickness of cerebral cortex in fetal age of 5 months was estimated at 0.61mm, and its growth pattern showed a rather rapid until the 8th month of fetal age, and thereafter with a relatively slower rate, it reached at mean value of 1. 59mm in the age of 10th month. The thickness of cortex was measured at 0. 63mm on the average for the brain with the weight of less than 50gm, and the relation between the thickness of cortex and the weight of brain showed that the development of cortex in thickness was rather rapid in growth rate as the weight of brain increased up to the level of 151-200gm, and then it developed relatively slowly as the brain got heavier reaching at the mean value of 1.64mm in thickness when the brain got weight of more than 401gm.
2. The differentiation of the lamination of cerebral cortex was found.to begin in the earlier part of 7th month of the fetal age or, in terms of the brain weight when it reached at 101.3gm on the average.
3. The "absolute" cell density of cerebral cortex was found to increase with fetal age until 6th month at which the density became maximum, and thereafter it started to decrease gradually as the fetus ages. As for the relationship between the ´absolute´ cell density and the brain weight, the highest mean value of density was of brain weighing 51-100gm, and thereafter it showed a gradual decrease.
4. It seemed that the nerve cells of cerebral cortex might be increasing in number rapidly until the 7th month of fetal life, and after that the number of nerve cells would not increase substantially.
5. The sexual difference could be observed neither in the thickness of cortex nor in the "relative" and the "absolute" cell densities.
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